Yu Han

The paper presents a comprehensive genetic perturbation dataset using Cell Painting to analyze gene expression effects in human cells, revealing novel gene clusters and functional relationships.

The paper introduces NeuroPainting, a morphological phenotyping method, and combines it with transcriptomics to identify cell-type-specific effects of the 22q11.2 deletion on mitochondrial structure and gene expression in astrocytes.

The paper develops a weakly supervised learning method to learn treatment effect representations from imaging data, improving downstream analysis performance.

Cell Painting images and profiles for 115,796 compounds in U2OS cells from 12 laboratories; 15.2% of analyzed compounds are phenotypically active, and cross-laboratory replicates cut reference-compound activity by 34%.

This study uses fMRI to examine theory of mind and emotion recognition in children with ASD compared to neurotypical children, finding impairments in ToM metrics and brain deficits related to emotion processing.