Matthew Tegtmeyer

Cellular morphology emerges from polygenic, distributed transcriptional variation

The paper shows cellular morphology is a polygenic trait by integrating perturbation data, genetic variation, and cross-modal modeling to predict morphology from gene expression.

Gene editing in "cell villages" enables exploring disease-relevant mutations in many genetic backgrounds

The paper uses village editing to study how genetic backgrounds affect the impact of schizophrenia-associated mutations in human neurons.

Functional consequences of genetic risk for neuropsychiatric conditions at chr22q

The paper identifies chr22q as a regulatory hub where genetic risk for neuropsychiatric conditions is associated with coordinated gene expression downregulation in brain tissue.

Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation

This study uses brain organoids and assembloids with microglia to show region-specific microglial diversity and their response to SCN2A mutation-induced neuronal hyperactivity.

Gene therapies alleviate absence epilepsy associated with Scn2a deficiency in DBA/2J mice

This paper shows that gene therapies can reduce absence seizures in DBA/2J mice with Scn2a deficiency by restoring NaV1.2 or introducing human KV1.1.

Human genetic variation shapes the response of neurons to interferons

The paper identifies genetic variants that influence neuronal responses to interferons by analyzing gene expression and STAT1 binding in iPSC-derived neurons.

Abnormal Lipid Metabolism and Altered Neuronal Support by Astrocytes Lacking Akap11, a Risk Gene for Schizophrenia and Bipolar Disorder

This study identifies AKAP11's role in regulating lipid metabolism and neuronal support in astrocytes, linking its dysfunction to schizophrenia and bipolar disorder risk.

Astrocytic-supplied cholesterol drives synaptic gene expression programs in developing neurons and downstream astrocytic transcriptional programs

The paper shows that astrocyte-supplied cholesterol drives synaptic gene expression in neurons and induces astrocytic transcriptional responses, linking lipid metabolism to neurodevelopmental disorders.

Combining NeuroPainting with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletion

The paper introduces NeuroPainting, a morphological phenotyping method, and combines it with transcriptomics to identify cell-type-specific effects of the 22q11.2 deletion on mitochondrial structure and gene expression in astrocytes.

Modeling interpretable correspondence between cell state and perturbation response with CellCap

CellCap models the relationship between cell state and perturbation response in single-cell experiments, revealing novel insights into cellular behavior.

High-dimensional phenotyping to define the genetic basis of cellular morphology

This study identifies genetic variants associated with cellular morphology using high-content imaging and genomic data from iPSCs.

Multi-donor human cortical Chimeroids reveal individual susceptibility to neurotoxic triggers

The paper introduces a multi-donor brain organoid model called Chimeroids to study individual genetic variation in neurotoxin susceptibility.

Early Alzheimer's disease pathology in human cortex is associated with a transient phase of distinct cell states

The paper identifies a transient hyperactive neuronal state in early Alzheimer's disease using single-nucleus transcriptomics from living patients.

Robust induction of functional astrocytes using NGN2 expression in human pluripotent stem cells

This study develops a rapid, scalable method to generate functional human astrocytes from pluripotent stem cells using NGN2 induction, showing high homogeneity and disease relevance.

Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons

The paper shows that astrocyte-neuron interactions enhance synaptic gene expression in neurons and correlate with schizophrenia risk genes.

The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia

This study investigates how the 22q11.2 deletion affects gene expression in neural progenitor cells and neurons, linking it to schizophrenia risk through altered presynaptic gene products.

Natural variation in gene expression and Zika virus susceptibility revealed by villages of neural progenitor cells

The paper identifies a common genetic variant in IFITM3 that explains most inter-individual variation in neural progenitor cell susceptibility to Zika virus using natural genetic variation and synthetic perturbations.

Mapping genetic effects on cellular phenotypes with "cell villages"

Census-seq pools cells from >100 human donors into "cell villages" and quantifies donor DNA before and after selection to map genetic effects on cellular traits.