Hypothermic and Normothermic Machine Perfusion Differentially Shape the Renal Cellular Landscape
Janine Siegle, Dörte Maria Kemper, Runze Zhu, Yiren Yang, Jay Wehenkel, Gishnu Harikumar Parvathy, Riccardo Camiletti, Karolin W. Hublitz, Efstathios G. Stamatiades, Vanessa Proß, Robert Labes, Michael Fähling, Roman David Bülow, Peter Boor, Katja Kotsch
This study compares hypothermic and normothermic machine perfusion in a murine kidney model, finding that NMP causes more severe tubular injury and immune cell mobilization compared to HMP.
bioRxiv · Oct 14, 2026 · PreprintImmunology