Benchmarking methods integrating GWAS and single-cell transcriptomic data for mapping trait-cell type associations
Ang Li, Peter C. Allen, Yong Wang, Haochen Cui, Tian Lin, Yuliangzi Sun, Xue Min Wang, Xiao Tan, Alicia Walker, Siqi Wang, Zheng Yao, Ruolan Zhao, Jian Yang, Shuyang Yao, Patrick F. Sullivan, , Jian Zeng
This paper benchmarks 20 methods for mapping trait-cell type associations by integrating GWAS and scRNA-seq data, finding CATCH to be the most robust approach.
medRxiv · May 24, 2025 · PreprintGenetic & Genomic Medicine