Ang Li

Polygenic effects on cortical size and ADHD converge on a mid-gestational progenitor-to-neuron transition programme

The paper identifies a mid-gestational molecular mechanism linking cortical size and ADHD through genetic and single-cell RNA sequencing analyses.

Quantifying annotation-stratified pleiotropy and co-polygenicity between complex traits

This paper introduces SBayesAPP, a Bayesian model that estimates annotation-stratified pleiotropy and co-polygenicity between complex traits using GWAS summary statistics, revealing cell-type-specific genetic correlations.

Genome-wide meta-analysis of panic attacks and disorder identifies genetic risk factors and implicates multiple body systems in panic and other psychiatric disorders

This study identifies genetic risk factors for panic attacks and disorder through genome-wide meta-analysis and links them to multiple body systems and neuronal functions.

Benchmarking methods integrating GWAS and single-cell transcriptomic data for mapping trait-cell type associations

This paper benchmarks 20 methods for mapping trait-cell type associations by integrating GWAS and scRNA-seq data, finding CATCH to be the most robust approach.

Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity

The paper integrates genomic data with single-cell transcriptomics to identify brain cell types and regions associated with psychiatric disorders and traits.

mBAT-combo: a more powerful test to detect gene-trait associations from GWAS data

mBAT-combo improves gene-trait association detection in GWAS by accounting for SNP effect directions, revealing masking effects in complex traits.

Assessing the variations in breast/ovarian cancer risk for Chinese BRCA1/2 carriers

This study identifies Chinese-specific BRCA1/2 mutation-associated cancer risk regions and characterizes mutation penetrance in a Chinese population.