RNA helicase Ddx21 safeguards fetal HSPC expansion by recruiting Kdm5a to epigenetically sustain ribosomal and hematopoietic gene transcription
Adrian On-Wah Leung, Chang Li, Xianyin Huang, Zhuming Fan, Yuning Chen, Jiaxing Liu, Hong-Man Lin, Xiaoming Cui, Fujia Zhang, Ruoxi Niu, Kam Tong Leung, Hoi‐Hung Cheung
This study identifies Ddx21's role in fetal hematopoiesis by showing it recruits Kdm5a to maintain epigenetic regulation of ribosomal and hematopoietic gene transcription, essential for HSPC expansion.
bioRxiv · Sep 4, 2025 · PreprintCell Biology