Author

Adrian On-Wah Leung

Chinese University of Hong KongORCID 0000-0002-9149-1989Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Chang LiiD· 1 shared Fujia Zhang· 1 shared Hoi‐Hung CheungiD· 1 shared Hong-Man Lin· 1 shared Jiaxing LiuiD· 1 shared Kam Tong LeungiD· 1 shared Ruoxi Niu· 1 shared Xianyin HuangiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Chang LiORCID

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1 paper

Recent·Most cited

RNA helicase Ddx21 safeguards fetal HSPC expansion by recruiting Kdm5a to epigenetically sustain ribosomal and hematopoietic gene transcription

Adrian On-Wah Leung, Chang Li, Xianyin Huang, Zhuming Fan, Yuning Chen, Jiaxing Liu, Hong-Man Lin, Xiaoming Cui, Fujia Zhang, Ruoxi Niu, Kam Tong Leung, Hoi‐Hung Cheung

This study identifies Ddx21's role in fetal hematopoiesis by showing it recruits Kdm5a to maintain epigenetic regulation of ribosomal and hematopoietic gene transcription, essential for HSPC expansion.

bioRxiv · Sep 4, 2025 · PreprintCell Biology