BiochemistryFEBS JournalPeer-reviewed
A somatic multiple myeloma mutation unravels a mechanism of oligomerization-mediated product inhibition in GGPPS
Ruba Yehia, Jasmína Mária Portašiková, Rut Mor Yosef…·Yoni Haitin
The paper identifies a mutation in GGPPS that disrupts inter-dimer interactions, leading to increased substrate affinity and product release, revealing product inhibition as a regulatory mechanism in GGPPS.
4 citations