Yoni Haitin

Mice with mono-allelic p.R37H Dhdds variant show aberrant glycosylation and interneuron deficits

This study describes a mouse model of DHDDS-CDG, showing seizures, myoclonus, and cognitive deficits linked to glycosylation defects and interneuron abnormalities.

Structural mechanisms of allosteric regulation in the human cis-prenyltransferase complex

This study identifies the structural basis of allosteric regulation in the human cis-prenyltransferase complex using a combination of experimental and computational methods.

Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels

The paper shows Gβγ interacts with GIRK2 and GIRK1/2 channels with affinities in the microM range, with GIRK1/2 having higher apparent affinity due to a unique Gβγ docking site.

Phage-encoded homing endonucleases attenuate bacterial immunity

This study shows phage-encoded homing endonucleases reduce bacterial immunity by inhibiting GAPS4, a DNase defense system, thereby enhancing phage fitness.

Ca2+-calmodulin regulates Kv7.1 channel gating by allosterically interfering with its inactivation path

The paper identifies the inactivation paths of Kv7.1 channels and shows how Ca2+-calmodulin prevents inactivation through allosteric interference.

A somatic multiple myeloma mutation unravels a mechanism of oligomerization-mediated product inhibition in GGPPS

The paper identifies a mutation in GGPPS that disrupts inter-dimer interactions, leading to increased substrate affinity and product release, revealing product inhibition as a regulatory mechanism in GGPPS.