Alan Kádek

De novo EHMT2 variants cause an autosomal dominant EHMT2-related Kleefstra syndrome via loss of G9a methyltransferase activity.

The paper identifies de novo EHMT2 variants causing an autosomal dominant Kleefstra syndrome by impairing G9a methyltransferase activity, mimicking EHMT1 haploinsufficiency.

A somatic multiple myeloma mutation unravels a mechanism of oligomerization-mediated product inhibition in GGPPS

The paper identifies a mutation in GGPPS that disrupts inter-dimer interactions, leading to increased substrate affinity and product release, revealing product inhibition as a regulatory mechanism in GGPPS.

X-ray Spectroscopy Meets Native Mass Spectrometry: Probing Gas-phase Protein Complexes

This paper discusses the use of X-ray spectroscopy and native mass spectrometry to study gas-phase protein complexes, showing fragmentation and dissociation patterns under different activation methods.

Glycan-induced structural activation softens the human papillomavirus capsid for entry through reduction of intercapsomere flexibility

This study investigates how glycan-induced structural activation of the HPV capsid facilitates entry by reducing intercapsomere flexibility.