Author

Ryan Agnew

Brigham and Women's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Aparna NathaniD· 2 shared Michelle L. CurtisiD· 2 shared Soumya RaychaudhuriiD· 2 shared Yuriy BaglaenkoiD· 2 shared Annelise Yoo Mah-SomiD· 1 shared David R. LiuiD· 1 shared Deepak A. RaoiD· 1 shared Dylan KotliariD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenomics

Aparna NathanORCID

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2 papers

Recent·Most cited

Reproducible single cell annotation of programs underlying T-cell subsets, activation states, and functions

Dylan Kotliar, Michelle L. Curtis, Ryan Agnew, Kathryn Weinand, Aparna Nathan, Yuriy Baglaenko, Kamil Slowikowski, Yu Zhao, Pardis Christine Sabeti, Deepak A. Rao, Soumya Raychaudhuri

The paper introduces TCAT, a pipeline to annotate T-cell GEPs, identifying 46 reproducible programs across diverse tissues and diseases.

Nature Methods · Sep 1, 2025Peer-reviewedGenomics

Defining the function of disease variants with CRISPR editing and multimodal single cell sequencing

Yuriy Baglaenko, Michelle L. Curtis, Majd Al Suqri, Ryan Agnew, Aparna Nathan, Hafsa M. Mire, Annelise Yoo Mah-Som, David R. Liu, Gregory A. Newby, Soumya Raychaudhuri

The paper uses CRISPR editing and multimodal single-cell sequencing to identify the functional effects of disease variants in primary human cells.

bioRxiv · Mar 28, 2024 · PreprintGenomics