Yu Zhao

This study identifies prolactin as a mediator linking psychological stress to psoriasis through a fibroblast-chemokine pathway, showing that targeting PRL signaling reduces disease severity in mice.

The paper introduces TCAT, a pipeline to annotate T-cell GEPs, identifying 46 reproducible programs across diverse tissues and diseases.

This study shows that the ISR/eIF2α pathway regulates cytokine mRNA translation in Trm cells, limiting their activity in homeostasis but enabling rapid response during inflammation or autoimmunity.

The paper constructs a cell-type-resolved chromatin accessibility atlas in the human intestine and identifies regulatory programs and genetic variants associated with Crohn's disease.

The paper compares TCR-pMHC prediction models and finds they lack generalization and robustness due to data dependency.

This study uses single-cell RNA sequencing to identify a mechanosensitive MRTF-SRF pathway in early diabetic nephropathy, validated in human datasets and ex vivo experiments.

This study compares immune responses and metabolism in SARS-CoV-2 and HIV-1 infections using single-cell transcriptomics, identifying shared and distinct features in 94,442 PBMCs from 16 patients.

The paper shows that neuronal cholesterol synthesis is critical for remyelination in chronic demyelination models and MS patients.