Use of Metagenomic Reference Materials to Compare Lysis and Extraction Methods Against a Known Input
Michael M. Weinstein, Braden T. Tierney, Elaine Wolfe, Shuiquan Tang, Venu Lagishetty, Jonathan P. Jacobs, Ryan Kemp, Christopher E. Mason
The paper evaluates lysis and extraction methods using metagenomic reference materials to identify optimal techniques and highlights biases in compositional metrics due to poor lysis.
bioRxiv · Jan 2, 2026 · PreprintMicrobiology