Braden T. Tierney

Diverse high-fat diets drive multi-omic reprogramming that persists after dietary reversal

The paper investigates how different high-fat diets affect host and microbiome multi-omic states over time and shows that some changes persist even after returning to a control diet.

The Oral Microbiome Is a Population-Scale Readout of the Exposome, Age, and Systemic Health

The paper develops a comprehensive oral microbiome atlas linking host features like age, disease, and exposures to 1,349 taxa in a 10,000-person US population, identifying 45,757 significant associations.

Use of Metagenomic Reference Materials to Compare Lysis and Extraction Methods Against a Known Input

The paper evaluates lysis and extraction methods using metagenomic reference materials to identify optimal techniques and highlights biases in compositional metrics due to poor lysis.

XTree enables memory-efficient, accurate short and long sequence alignment to millions of genomes across the tree of life

XTree aligns sequencing reads to large genome databases efficiently and accurately, outperforming existing tools in precision and recall.

The Two Frontiers Project Field Handbook and OpenTools: Standardizing microbial fieldwork for biobank-scale sequencing and culturomics

The paper provides a standardized fieldwork handbook and open tools for microbial sampling, sequencing, and culturing at biobank scale.

Modular metagenomic analysis of pan-domain symbioses with MAGUS

The paper introduces MAGUS, a toolkit for analyzing metagenomic data from eukaryote-dominated symbiotic communities, and demonstrates its ability to resolve multiple genomes and gene catalogs from coral and hydrozoan samples.

Spaceflight alters host-gut microbiota interactions

This study identifies spaceflight-induced changes in gut microbiota and host gene expression in mice, suggesting altered host-microbiome interactions contribute to spaceflight-related pathologies.

Collection of Biospecimens from the Inspiration4 Mission Establishes the Standards for the Space Omics and Medical Atlas (SOMA)

This paper describes the collection and processing of biospecimens from the Inspiration4 space mission to establish standards for space omics and medical research.

CAMP: A modular metagenomics analysis system for integrated multi-step data exploration

CAMP provides a modular metagenomics analysis system that enables scalable, extensible workflows with integrated data visualization and reporting.

The predictive power of the microbiome exceeds that of genome-wide association studies in the discrimination of complex human disease

This study compares microbiome and genome-wide association study predictive power for 13 diseases, finding microbiome indicators outperform genetic variants in disease discrimination.

Aether: Leveraging Linear Programming For Optimal Cloud Computing In Genomics

Aether uses linear programming to optimally deploy cloud resources for genomics tasks, achieving cost savings and efficiency in metagenomic assembly.