The BMP antagonist Gremlin1 contributes to the development of cortical excitatory neurons, motor balance and fear responses
Mari Ichinose, Nobumi Suzuki, Tongtong Wang, Hiroki Kobayashi, Laura Vrbanac, Jia Q. Ng, Josephine A. Wright, Tamsin R.M. Lannagan, Krystyna A. Gieniec, Martin David Lewis, Ryota Ando, Atsushi Enomoto, Simon Andrea Koblar, Paul Quinton Thomas, Daniel L. Worthley, Susan Lesley Woods
This study identifies Grem1 as a marker for neuroprogenitors generating cortical glutamatergic neurons and shows that its deletion causes cortical and behavioral defects in mice.
Development · Jul 1, 2021Peer-reviewedDevelopmental Biology