Atsushi Enomoto

This study shows that targeting the AMPK-MAPK axis in cancer-associated fibroblasts suppresses PDAC growth in fly and mouse models by restoring AMPK activity and inhibiting fibroblast activation.

This study shows that locally produced C3 in cancer-associated fibroblasts, not circulating C3, determines immune checkpoint blockade efficacy by modulating myeloid cell infiltration.

DeepCOLOR identifies cell-cell interactions by reconstructing spatial colocalization maps from single-cell and spatial transcriptomes in various tissues.

This study identifies Grem1 as a marker for neuroprogenitors generating cortical glutamatergic neurons and shows that its deletion causes cortical and behavioral defects in mice.