Pan-cancer analysis reveals context-dependent roles of LINE-1 ORF1p in immune regulation and copy number alterations
Efiyenia Ismini Kaparos, Wenjing Zhang, Ryusei Miyanaga, Wilson McKerrow, Jef D. Boeke, Teresa Davoli, Paolo Mita, Kelly V. Ruggles, David Fenyö
The paper analyzes ORF1p expression across cancers, finding it correlates with immune suppression in some tumors and activation in others, linked to copy number alterations.
bioRxiv · Oct 3, 2025 · PreprintGenomics