Wilson McKerrow

Neoantigen-reactive CD8+ T cell engagement marks exceptional survivors of pancreatic cancer

The paper identifies TIE CD8+ T cell clonotypes associated with prolonged survival in pancreatic cancer patients and links resistance to stromal and immune barriers.

Pan-cancer analysis reveals context-dependent roles of LINE-1 ORF1p in immune regulation and copy number alterations

The paper analyzes ORF1p expression across cancers, finding it correlates with immune suppression in some tumors and activation in others, linked to copy number alterations.

LINE-1 ORF1p is a shared and immunogenic antigen in cancer

This study identifies LINE-1 ORF1p as a shared and immunogenic antigen in cancer, showing its expression in tumors, MHC class I presentation, and in vitro immunogenicity.

LINE-1 Retrotransposon expression in cancerous, epithelial and neuronal cells revealed by 5'-single cell RNA-Seq

The paper develops a method to measure LINE-1 retrotransposon expression in single cells and identifies its presence in epithelial and neuronal cells, with age-related increases.

L1EM: A tool for accurate locus specific LINE-1 RNA quantification

L1EM quantifies LINE-1 RNA at specific genomic loci using expectation maximization, distinguishing retrotransposition-capable transcripts from non-functional ones.