Author

Ryutaro Hanyu

Brain Research Institute, Niigata University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Akihiro SugaiiD· 2 shared Aya Washida· 2 shared Genri ToyamaiD· 2 shared Osamu OnoderaiD· 2 shared Shingo KoideiD· 2 shared Takuma YamagishiiD· 2 shared Ekaterina Nadbitova· 1 shared Taisuke KatoiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Akihiro SugaiORCID

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2 papers

Recent·Most cited

Export-biased, 3'UTR-preserving TDP-43 model links nuclear loss to cytoplasmic aggregation in ALS/FTLD

Genri Toyama, Shingo Koide, Takuma Yamagishi, Aya Washida, Ryutaro Hanyu, Osamu Onodera, Akihiro Sugai

This study shows that export-biased TDP-43 with intact 3' UTR leads to cytoplasmic aggregation and splicing defects, even when exogenous levels match endogenous, suggesting loss of nuclear function.

bioRxiv · Nov 12, 2025 · PreprintMolecular Biology

ASO-enhancement of TARDBP exitron splicing mitigates TDP-43 proteinopathies

Takuma Yamagishi, Shingo Koide, Genri Toyama, Aya Washida, Yumi Yamada, Ryutaro Hanyu, Ekaterina Nadbitova, Yuka Mitsuhashi Koike, Takuya Konno, Tomohiko Ishihara, Taisuke Kato, Osamu Onodera, Akihiro Sugai

This paper shows that enhancing TARDBP exitron splicing reduces TDP-43 aggregation and neurodegeneration in disease models using ASOs.

bioRxiv · Jul 22, 2024 · PreprintNeuroscience