Engineering SIRPα conformational plasticity to reveal a cryptic pocket suitable for structure-based drug design
Martin Storder, Sarah Barelier, Florence Cordier, Taher Yacoub, Laura Ilari, Karine Barral, S Mahmoodi, Magalí Sáez‐Ayala, Sébastien Combes, S. Betzi, Carine Derviaux, A Ulliana, F Torres, J Rubin, Philippe Roche, , TW Miller
This paper identifies a cryptic pocket in SIRPα that can be targeted for drug design by engineering conformational changes to expose it.
bioRxiv · Dec 23, 2025 · PreprintBiochemistry