BiochemistrybioRxivPreprint
Engineering SIRPα conformational plasticity to reveal a cryptic pocket suitable for structure-based drug design
Martin Storder, Sarah Barelier, Florence Cordier…·TW Miller
This paper identifies a cryptic pocket in SIRPα that can be targeted for drug design by engineering conformational changes to expose it.
DOI 10.64898/2025.12.10.693509