A phylogeny-aware GWAS framework to correct for heritable pathogen effects on infectious disease traits
Sarah Nadeau, Christian Wandall Thorball, Roger D. Kouyos, Huldrych F. Günthard, Jürg Böni, Sabine Yerly, Matthieu Perreau, Thomas Klimkait, Andri Rauch, Hans Hellmuth Hirsch, Matthias L. Cavassini, Pietro Vernazza, Enos Bernasconi, Jacques Fellay, Venelin Mitov, , S Yerly
This paper introduces a phylogeny-aware GWAS framework to correct for heritable pathogen effects on infectious disease traits, showing improved detection of host genetic variants in simulations and applied to HIV-1 data.
Molecular Biology and Evolution · Aug 1, 2022Peer-reviewedGenetic & Genomic Medicine