NGLY1 knockdown or pharmacological inhibition induces cellular autophagy
S. H. Needs, M. D. Bootman, J. Grotzke, H. B. Kramer, S. A. Allman
The paper shows that NGLY1 inhibition via Z-VAD-fmk or siRNA increases autophagy in HEK 293 cells without affecting autophagic flux or ER stress.
bioRxiv · Dec 5, 2020Cell Biology