M. D. Bootman

Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing Mcl-1-addicted cancer cells

This paper shows that BAPTAi inhibits PFKFB3, reducing mTORC1-driven Mcl-1 translation and killing Mcl-1-dependent cancer cells, independent of Ca2+ signaling.

NGLY1 knockdown or pharmacological inhibition induces cellular autophagy

The paper shows that NGLY1 inhibition via Z-VAD-fmk or siRNA increases autophagy in HEK 293 cells without affecting autophagic flux or ER stress.