SARS-CoV-2 viroporin triggers the NLRP3 inflammatory pathway
H. Xu, S. A. Chitre, I. A. Akinyemi, J. C. Loeb, J. A. Lednicky, M. T. McIntosh, S. Bhaduri-McIntosh
This paper identifies ORF3a as a SARS-CoV-2 viroporin that activates the NLRP3 inflammasome by causing potassium efflux, leading to IL-1β expression and inflammation.
bioRxiv · Oct 27, 2020 · PreprintMicrobiology