M. T. McIntosh

Beta human papillomavirus 8E6 promotes alternative end-joining

This study shows HPV8 E6 promotes alternative end-joining (Alt-EJ) by interacting with p300, leading to increased genomic instability and deletions with Alt-EJ signatures.

SARS-CoV-2 viroporin triggers the NLRP3 inflammatory pathway

This paper identifies ORF3a as a SARS-CoV-2 viroporin that activates the NLRP3 inflammasome by causing potassium efflux, leading to IL-1β expression and inflammation.