Co-inhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription
D. P. Cameron, J. Grosser, S. Ladigan, V. Kuzin, E. Iliopoulou, A. Wiegard, H. Benredjem, S. T. Liffers, S. Lueong, P. F. Cheung, D. Vangala, M. Pohl, R. Viebahn, C. Teschendorf, H. Wolters, , L. Baranello
The paper shows that combining TOP1 and BRD4 inhibitors selectively kills pancreatic cancer cells by inducing readthrough transcription, without harming normal cells.
bioRxiv · Feb 10, 2023Cancer Biology