Retinoic acid and proteotoxic stress induce AML cell death overcoming stromal cell protection
F. Liccardo, M. Sniegocka, C. Tito, A. Iaiza, T. Ottone, M. Divona, S. Travaglini, M. Mattei, R. Cicconi, S. Miglietta, G. Familiari, S. A. Nottola, V. Petrozza, L. Tamagnone, M. T. Voso, , F. Fazi
This study shows that retinoic acid, bortezomib, and arsenic trioxide combined with ascorbic acid induce AML cell death in FLT3-ITD+ cells by overcoming stromal cell protection.
bioRxiv · Feb 20, 2023Cancer Biology