BiochemistrybioRxiv
Boosting detection of low abundance proteins in thermal proteome profiling experiments by addition of an isobaric trigger channel to TMT multiplexes
S. A. Peck Justice, N. A. McCracken, J. F. Victorino…·A. L. Mosley
The paper introduces an isobaric trigger channel in TMT multiplexes to improve detection of low abundance proteins in thermal proteome profiling, enhancing detection of CPF subunits without affecting Tm calculations.
DOI 10.1021/acs.analchem.1c00012