The toxic nature of murine amylin and the immune responsivity of pancreatic islet to conformational antibody in mice
L. C. S. Erthal, L. Jotha-Mattos, F. A. Lara, S. A. Reis, B. M. O. Pascarelli, C. M. Costa, K. L. A. Souza, L. M. T. R. Lima
This study shows that murine amylin forms toxic oligomers and amyloid fibrils, and is recognized by an anti-oligomer antibody in pancreatic islets of non-transgenic mice.
bioRxiv · Aug 12, 2017Biochemistry