A Polymorphic Residue That Attenuates the Antiviral Potential of Interferon Lambda 4 in Hominid Lineages
C. G. G. Bamford, E. Aranday-Cortes, I. Cordeiro Filipe, S. Sukumar, D. Mair, A. da Silva Filipe, J. L. Mendoza, K. C. Garcia, S. Fan, S. A. Tishkoff, J. McLauchlan
The paper identifies a polymorphic residue in IFN{lambda}4 that reduces its antiviral activity in humans compared to other hominids, contributing to differences in HCV clearance.
bioRxiv · Mar 26, 2018Immunology