Author

J. L. Mendoza

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Approach:statistical model· 1

Frequent Co-Authors

A. da Silva Filipe· 1 shared C. G. G. Bamford· 1 shared C. M. Horvath· 1 shared D. Mair· 1 shared E. Aranday-Cortes· 1 shared E. L. Nichols· 1 shared E. Özkan· 1 shared I. Cordeiro Filipe· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperImmunology

A. da Silva Filipe

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Enhanced Complex Stability and Optimal JAK Geometry are Pivotal for a Potent Type III Interferon Response

T. Aung, C. M. Horvath, J. L. Mendoza

This study identifies that optimizing JAK-JAK geometry enhances type III IFN signaling potency by 2-3 logs, offering insights into cytokine signaling and therapeutic development.

bioRxiv · Sep 27, 2022 · PreprintCell Biology

Structural insights into the formation of repulsive Netrin guidance complexes

J. M. Priest, E. L. Nichols, J. L. Mendoza, K. Shen, E. Özkan

This study reveals that Netrin-UNC-5 interactions form glycosaminoglycan-regulated large complexes mediating repulsive guidance signals during cell migration.

bioRxiv · Sep 3, 2022Biochemistry

A Polymorphic Residue That Attenuates the Antiviral Potential of Interferon Lambda 4 in Hominid Lineages

C. G. G. Bamford, E. Aranday-Cortes, I. Cordeiro Filipe, S. Sukumar, D. Mair, A. da Silva Filipe, J. L. Mendoza, K. C. Garcia, S. Fan, S. A. Tishkoff, J. McLauchlan

The paper identifies a polymorphic residue in IFN{lambda}4 that reduces its antiviral activity in humans compared to other hominids, contributing to differences in HCV clearance.

bioRxiv · Mar 26, 2018Immunology