Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
7 papers
Recent·Most cited
J. N. Ranum, M. P. Ledwith, F. G. Alnaji, M. Diefenbacher, R. Orton, E. Sloan, M. Guereca, E. M. Feltman, K. Smollett, A. da Silva Filipe, M. Conley, A. B. Russell, C. B. Brooke, E. Hutchinson, A. Mehle
The paper identifies cryptic proteins from deletion-containing viral genomes that inhibit influenza virus replication and expand its proteome.
bioRxiv · Dec 12, 2023Microbiology
E. Sugrue, A. Wickenhagen, N. Mollentze, M. A. Aziz, V. B. Sreenu, S. Truxa, L. Tong, A. da Silva Filipe, D. L. Robertson, J. Hughes, S. J. Rihn, S. J. Wilson
The paper identifies that transmitted HIV-1's interferon resistance stems from enhanced replicative fitness rather than specific IFN resistance.
bioRxiv · Dec 18, 2021Microbiology
A. M. Szemiel, A. Merits, R. J. Orton, O. MacLean, A. Wickenhagen, G. Lieber, R. M. Pinto, M. L. Turnbull, S. Wang, D. Mair, A. da Silva Filipe, B. J. Willett, S. J. Wilson, A. H. Patel, E. C. Thomson, , M. E. Stewart
This study shows that in vitro evolution of SARS-CoV-2 under remdesivir selects for resistant mutations, but these mutations do not spread widely in global variants.
bioRxiv · Feb 1, 2021Microbiology
E. C. Thomson, L. E. Rosen, J. G. Shepherd, R. Spreafico, A. da Silva Filipe, J. A. Wojcechowskyj, C. Davis, L. Piccoli, D. J. Pascall, J. Dillen, S. Lytras, N. Czudnochowski, R. Shah, M. Meury, N. Jesudason, , J. Nichols
The paper shows the N439K SARS-CoV-2 spike variant maintains replication fitness while evading antibody neutralization.
bioRxiv · Nov 4, 2020Microbiology
J. J. Clark, J. Gilray, R. J. Orton, M. Baird, G. S. Wilkie, A. da Silva Filipe, N. Johnson, C. J. McInnes, A. Kohl, R. Biek
This study sequences 22 louping ill virus isolates to analyze genomic diversity and evolutionary history, finding low diversity, limited positive selection, and challenges in estimating molecular clock rates for tick-borne flaviviruses.
bioRxiv · Feb 14, 2020Evolutionary Biology
D. J. Pascall, K. Nomikou, E. Breard, S. Zientara, A. da Silva Filipe, B. Hoffmann, M. Jacquot, J. B. Singer, K. De Clercq, A. Botner, C. Sailleau, C. Viarouge, C. Batten, G. Puggioni, C. Ligios, , M. Palmarini
This study uses genomic data to show that a BTV-8 virus strain re-emerged in 2015 without significant evolution, suggesting accidental release rather than natural persistence.
bioRxiv · Dec 11, 2019Evolutionary Biology
C. G. G. Bamford, E. Aranday-Cortes, I. Cordeiro Filipe, S. Sukumar, D. Mair, A. da Silva Filipe, J. L. Mendoza, K. C. Garcia, S. Fan, S. A. Tishkoff, J. McLauchlan
The paper identifies a polymorphic residue in IFN{lambda}4 that reduces its antiviral activity in humans compared to other hominids, contributing to differences in HCV clearance.
bioRxiv · Mar 26, 2018Immunology