Energy scarcity and impaired mitochondrial translation induce perinuclear stress granule clustering
U. Fernadez-Pelayo, M. Munoz-Oreja, M. Villar-Fernandez, A. Lopez de Arbina, I. Aiestaran- Zelaia, M. J. Sanchez-Guisado, B. Pantic, A. Elicegui, M. Zufiria, P. Iruzubieta, M. Sagartzazu-Aizpurua, J. M. Aizpurua, M. Gegg, S. Alonso-Martin, J. Ruiz-Cabello, , I. Holt
The paper shows that energy scarcity and mitochondrial translation impairment cause ALS-FTD-related proteins to form perinuclear stress granule clusters, potentially leading to pathological inclusions.
bioRxiv · Feb 1, 2024 · PreprintCell Biology