J. Ruiz-Cabello

Energy scarcity and impaired mitochondrial translation induce perinuclear stress granule clustering

The paper shows that energy scarcity and mitochondrial translation impairment cause ALS-FTD-related proteins to form perinuclear stress granule clusters, potentially leading to pathological inclusions.

Activation of HIF2 leads to vascular remodeling and inflammation, coronary thrombosis and arterial dilation, recapitulating cardiac involvement of Kawasaki disease.

This study shows that activating HIF2 causes vascular remodeling, inflammation, and coronary issues similar to Kawasaki disease, using a new mouse model and human tissue analysis.

HAP-multitag, a PET and positive MRI contrast nanotracer for the longitudinal characterization of vascular calcifications in atherosclerosis

This paper develops HAP-multitag, a nanotracer for PET and MRI to detect vascular calcifications in atherosclerosis, showing uptake dependent on calcification progression.

Mitochondrial Na+ controls oxidative phosphorylation and hypoxic redox signalling

This study shows that mitochondrial Na+ acts as a second messenger regulating OXPHOS and ROS production through interactions with phospholipids during hypoxia.