S. Ambros

Adaptation of turnip mosaic virus to Arabidopsis thaliana involves rewiring of VPg - host proteome interactions

The paper investigates how mutations in TuMV's VPg protein affect its interactions with host proteins in Arabidopsis thaliana, revealing their impact on viral adaptation and plant tolerance.

Phenotypic and genomic changes during Turnip mosaic virus adaptation to Arabidopsis thaliana mutants lacking epigenetic regulatory factors

This study shows RNA viruses adapt to epigenetic plant defenses by increasing infectivity, virulence, and viral load, with adaptation primarily targeting the VPg protein.

Defects in plant immunity modulate the rates and patterns of RNA virus evolution

This study shows that host immunity differences affect RNA virus evolution rates and patterns, with resistant hosts driving faster adaptation and permissive hosts selecting for specialist viruses.

Engineered Genetic Redundancy Relaxes Selective Constraints upon Endogenous Genes in Viral RNA Genomes

This study shows that engineered genetic redundancy in viral RNA genomes reduces the negative impact of deleterious mutations on fitness and virulence.

Diminishing returns of inoculum size on the rate of a plant RNA virus evolution

The paper tests if increasing inoculum size reduces evolutionary rate in a plant RNA virus, finding mixed results across fitness traits.

Viral fitness predicts the magnitude and direction of perturbations in the infected host transcriptome

The paper shows that viral fitness correlates with changes in host gene expression, identifying genes and pathways affected by different viral genotypes.