Conserved degronome features governing quality control-associated proteolysis
B. Mashahreh, S. Armony, K. E. Johansson, A. Chappleboim, N. Friedman, R. Gardner, R. Hartmann-Petersen, K. Lindorff-Larsen, T. Ravid
The paper identifies conserved degron features in yeast, viruses, and humans that govern quality control proteolysis, showing transmembrane domain-like sequences are key determinants of protein half-life.
bioRxiv · Apr 6, 2022 · PreprintCell Biology