R. Gardner

Chlamydia muridarum Causes Persistent Subclinical Infection and Elicits Innate and Adaptive Immune Responses in C57BL/6J, BALB/cJ and J:ARC(S) Mice Following Exposure to Shedding Mice

This study shows that C57BL/6J, BALB/cJ, and J:ARC(S) mice develop persistent subclinical Chlamydia muridarum infections with immune responses, suggesting the need to exclude Cm from mouse colonies used in GI disease research.

Interferon response and epigenetic modulation by SMARCA4 mutations drive ovarian tumor immunogenicity

This study shows that SMARCA4 mutations in ovarian cancer increase immunogenicity through interferon response and epigenetic changes, enhancing T cell and NK cell activity in the tumor microenvironment.

Conserved degronome features governing quality control-associated proteolysis

The paper identifies conserved degron features in yeast, viruses, and humans that govern quality control proteolysis, showing transmembrane domain-like sequences are key determinants of protein half-life.

Acute ethanol stress induces sumoylation of conserved chromatin structural proteins in Saccharomyces cerevisiae

This study shows that acute ethanol stress in yeast induces transient sumoylation of chromatin structural proteins, with chronic effects at higher ethanol concentrations.

Can quantifying morphology and TMEM119 expression distinguish between microglia and infiltrating macrophages after ischemic stroke and reperfusion in male and female mice?

This study investigates whether morphology and TMEM119 expression can distinguish microglia from infiltrating macrophages after ischemic stroke in male and female mice, finding that TMEM119 is not a reliable marker in this context.

Tsetse salivary glycoproteins are modified with paucimannosidic N-glycans, are recognised by C-type lectins and bind to trypanosomes

The paper characterizes the N-glycan profile of tsetse salivary glycoproteins and shows they bind trypanosomes and are recognized by C-type lectins.

A combined characterization of coelomic fluid cell types in the spiny starfish Marthasterias glacialis: inputs from flow cytometry and imaging

The paper characterizes coelomic fluid cell types in the spiny starfish Marthasterias glacialis using flow cytometry and imaging, identifying two main populations with distinct morphological and functional features.