Haptoglobin buffers lipopolysaccharides to safeguard against aberrant NFκB activation
L. Zein, J. Grossmann, H. Swoboda, C. Borgel, B. Wilke, S. Awe, A. Nist, T. Stiewe, O. Stehling, S.-A. Freibert, T. Adhikary, H.-R. Chung
This study shows haptoglobin binds and buffers lipopolysaccharides to delay NFκB activation in macrophages, suggesting its role in preventing aberrant inflammation.
bioRxiv · Nov 22, 2022 · PreprintImmunology