Doxycycline interferes with tau amyloid aggregation abolishing its associated neuronal toxicity
L. Medina, F. Gonzalez Lizarraga, A. Dominguez Meijide, D. Ploper, V. Parrales, S. Sequeira, M. S. Cima Omorri, M. Zweckstetter, E. del Bel, P. P. Michel, T. Fleming Outeiro, R. Raisman-Vozari, R. N. Chehin, S. B. Socias
This study shows doxycycline reduces tau protein aggregation and toxicity in cell-free and cell culture systems, suggesting its potential repurposing for tauopathies.
bioRxiv · Nov 18, 2020 · PreprintBiophysics