Mitochondrial topoisomerase I (Top1MT) prevents the onset of metabolic dysfunction-associated steatohepatitis (MASH) in mice
S. Baechler, LK Saha, VM Factor, C Chitnis, Aseem Dhall, D Becker, Jens Uwe Marquardt, Yves G. Pommier
This study shows that Top1MT deficiency in mice leads to severe MASH with liver steatosis, inflammation, and fibrosis after a high-fat diet.
bioRxiv · Sep 5, 2024 · PreprintMolecular Biology