Jens Uwe Marquardt

This study identifies a sex-specific mechanism where platelet C5aR1 mediates ischemia-driven revascularization through estradiol-dependent CXCL4 release, explaining sex differences in cardiovascular outcomes.

This study shows that platelet C5aR1 worsens myocardial infarction by promoting neutrophil activation and NET release, and that targeting it can reduce cardiac damage.

This study defines the spatial architecture of intrahepatic cholangiocarcinoma using single-cell spatial proteomics and a graph-based deep learning framework to identify multicellular spatial patterns and their association with patient outcomes.

The paper uses spatial single-cell data to identify tumor cell clusters (villages) and their microenvironmental dependencies, showing their impact on patient outcomes.

This study shows that hepatocyte circadian clocks regulate cholesterol metabolism and protect against MASH, with Bmal1 playing a specific role in this process.

This study shows that Top1MT deficiency in mice leads to severe MASH with liver steatosis, inflammation, and fibrosis after a high-fat diet.

This paper presents a high-sensitivity targeted method to measure pri-miRNA processing efficiency in clinical samples and identifies 24 microRNAs with significant changes in processing efficiency between normal liver and hepatocellular carcinoma.