Liton Kumar Saha

This study identifies TOP3A's role in ALT telomere maintenance, showing its enrichment at ALT telomeres and its impact on TERRA and TERF2 stability.

This study shows that Top3b loss accelerates lymphoma development and causes immune dysregulation in mice through R-loop accumulation and immune signaling activation.

This study identifies FA-induced DNA-protein crosslinks (DPCs) and discovers that FEN1 repairs them via PARylation, revealing a novel PARP1-FEN1 pathway for DPC repair.

This study shows that Top1MT deficiency in mice leads to severe MASH with liver steatosis, inflammation, and fibrosis after a high-fat diet.

The paper maps genome-wide topoisomerase binding sites to identify TOP3A as a sensor of transcription-replication conflicts.