Cancer BiologybioRxiv
Endothelial Rbpj is essential for the education of tumour-associated macrophages
R. Mülfarth, E. Alsina-Sanchis, I. Moll…·J. Rodriguez-Vita
This study shows that endothelial Rbpj promotes TAM education in EOC by regulating CXCL2, which drives CD44 expression and cholesterol depletion in TAMs, creating an immunosuppressive TME.
DOI 10.1158/0008-5472.can-22-0076