Intense light-mediated circadian cardioprotection via transcriptional reprogramming of the endothelium
Y. Oyama, C. M. Bartman, S. Bonnie, J. S. Lee, L. A. Walker, J. Han, C. H. Borchers, P. M. Buttrick, C. Aherne, N. Clendenen, S. P. Colgan, T. Eckle
This study identifies circadian PER2 amplitude enhancement in endothelial cells as a novel cardioprotective strategy that mimics HIF1A metabolic adaptation during myocardial ischemia.
bioRxiv · Jul 12, 2019Cell Biology