Citrullination of pyruvate kinase by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation.
I. Davidson, S. Coassolo, G. Davidson, L. Negroni, G. Gambi, S. Daujat, C. Romier
The paper shows that CHD4 regulates PADI1 and PADI3 to citrullinate PKM2, altering its activity and promoting glycolysis and cancer cell proliferation.
bioRxiv · Jan 9, 2020Cancer Biology