L. Negroni

Uncovering the BIN1-SH3 interactome underpinning centronuclear myopathy

The paper identifies new BIN1 interaction partners and shows how BIN1 mutations disrupt proteome-wide interactions, contributing to centronuclear myopathy.

Changes in social behaviour with alterations of MAPK3 and KCTD13/CUL3 pathways in two new outbred rat models for the 16p11.2 syndromes with autism spectrum disorders.

This paper creates two rat models with 16p11.2 CNVs to study social behavior and finds altered MAPK3 and CUL3 pathways with sexual dimorphism in phenotypes.

The E2F4/p130 repressor complex cooperates with oncogenic ΔNp73α to promote cell survival in human papillomavirus 38 E6/E7-transformed keratinocytes and in cancer cells

This paper identifies a novel interaction between ΔNp73 and the E2F4/p130 repressor complex that promotes cell survival in HPV-transformed keratinocytes and cancer cells.

Reflux of Endoplasmic Reticulum proteins to the cytosol yields inactivation of tumor suppressors

The paper identifies a mechanism where ER proteins are refluxed to the cytosol, inactivating tumor suppressors like p53 in glioblastoma cells.

Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs.

This study identifies RtcB tyrosine phosphorylation as a regulatory mechanism controlling IRE1's dual RNase activities, influencing cell survival or death during ER stress.

Novel IRE1-dependent proinflammatory signaling controls tumor infiltration by myeloid cells.

This study identifies an IRE1-dependent proinflammatory signaling pathway in glioblastoma that promotes tumor invasion, angiogenesis, and myeloid cell infiltration.

Citrullination of pyruvate kinase by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation.

The paper shows that CHD4 regulates PADI1 and PADI3 to citrullinate PKM2, altering its activity and promoting glycolysis and cancer cell proliferation.