Prostaglandin E2 directly inhibits the conversion of inducible regulatory T cells through EP2 and EP4 receptors via antagonizing TGF-β signalling
M. Goepp, S. Crittenden, Y. Zhou, A. G. Rossi, S. Narumiya, C. Yao
This study shows PGE2 inhibits inducible Treg cell differentiation via EP2 and EP4 receptors by blocking TGF-β signaling in vitro and in vivo.
bioRxiv · Apr 19, 2021Immunology