Author

S. Narumiya

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. Yao· 2 shared M. Goepp· 2 shared Y. Zhou· 2 shared A. A. A. Pezzulo· 1 shared A. G. Rossi· 1 shared A. Rossi· 1 shared B. Zhang· 1 shared C. Robb· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

C. Yao

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Calcium transients trigger switch-like discharge of prostaglandin E2 (PGE2) in an extracellular signal-regulated kinase-dependent manner

T. Watabe, S. Yamahira, K. Takakura, D. Thumkeo, S. Narumiya, M. Matsuda, K. Terai

The paper shows calcium transients trigger switch-like PGE2 discharge in MDCK cells and mouse epidermis, dependent on ERK activity.

bioRxiv · Feb 1, 2023 · PreprintCell Biology

Metabolic regulation by prostaglandin E2 impairs lung group 2 innate lymphoid cell responses

C. Robb, Y. Zhou, J. Felton, B. Zhang, M. Goepp, P. Jheeta, D. Smyth, R. Breyer, S. Narumiya, H. McSorley, R. Maizels, J. Schwarze, A. Rossi, C. Yao

This study identifies that PGE2-EP2 signaling suppresses lung ILC2 responses and eosinophilic inflammation, while EP4 agonism restricts these responses, offering potential therapeutic targets for asthma and NERD.

bioRxiv · Dec 23, 2021Immunology

Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19

S. Perlman, L. Y. R. Wong, J. Zheng, K. Wilhelmsen, K. Li, M. E. Ortiz Bezara, N. J. Schnicker, A. A. A. Pezzulo, P. J. Szachowicz, K. Klumpp, F. Aswad, J. Rebo, S. Narumiya, M. Murakami, D. Meyerholz, , P. B. McCray

This study identifies the PLA2G2D-PGD2/DP1 pathway as a therapeutic target for severe COVID-19 in middle-aged mice, showing protection through DP1 antagonism.

bioRxiv · Apr 20, 2021 · PreprintMicrobiology

Prostaglandin E2 directly inhibits the conversion of inducible regulatory T cells through EP2 and EP4 receptors via antagonizing TGF-β signalling

M. Goepp, S. Crittenden, Y. Zhou, A. G. Rossi, S. Narumiya, C. Yao

This study shows PGE2 inhibits inducible Treg cell differentiation via EP2 and EP4 receptors by blocking TGF-β signaling in vitro and in vivo.

bioRxiv · Apr 19, 2021Immunology