The disease associated Tau35 fragment has an increased propensity to aggregate compared to full-length tau
C. Lyu, S. Da Vela, Y. K. Al-Hilaly, K. Marshall, R. Thorogate, D. Svergun, L. Serpell, A. Pastore, D. P. Hanger
The paper compares the aggregation propensity of Tau35 to full-length tau, finding Tau35 aggregates more readily and forms denser structures.
bioRxiv · Jul 8, 2021Biophysics